Piper aduncum L. (matico) utilizado como tratamiento para el daño pulmonar y Covid-19

Resumen El objetivo principal fue conocer las propiedades antimicrobianas del Piper aduncum L. (matico) para el tratamiento de prevención del Covid-19. El aceite esencial, como los extractos de las hojas y la corteza son muy valiosos como agente cicatrizante, antibacterianos y antifúngico. De esta manera los componentes los flavonoides presentes en el aceite esencial de Piper aduncum L. (matico) fortifican la conectividad de los tejidos mediante la inhibición de algunas de las enzimas que pueden hidrolizar el proteoglicano y la malla proteica, lo cual podría aumentar el efecto antibacteriano al obstaculizar la difusión de la infección al tejido, su actividad antibacterial frente a Staphylococus aureus y Echerichia coli; obteniéndose como resultado que los metabolitos secundarios como flavonoides, compuestos fenólicos, esteroides y alcaloides cuentan con acción antibacterial. La planta del Piper aduncum L. (matico) es un buen cicatrizante y antifúngico se está comercializando como producto farmacéutico en gel. La conclusión que el aceite esencial de Piper aduncum L. (matico) no ayuda a prevenir ni mucho menos a eliminar el nuevo coronavirus y su composición química del matico solo ayuda a prevenir algunas de los síntomas del Covid 19.

Abstract The main objective was to know the antimicrobial properties of Piper aduncum L. (matico) for the prevention treatment of Covid-19. The essential oil, like the extracts of the leaves and the bark, are very valuable as a healing agent, antibacterial and antifungal. In this way, the flavonoid components present in the essential oil of Piper aduncum L. (matico) fortify the connectivity of the tissues by inhibiting some of the enzymes that can hydrolyze the proteoglycan and the protein mesh, which could increase the effect antibacterial by hindering the spread of the infection to the tissue, its antibacterial activity against Staphylococus aureus and Echerichia coli; As a result, secondary metabolites such as flavonoids, phenolic compounds, steroids and alkaloids have antibacterial action. The Piper aduncum L. (matico) plant is a good healing and antifungal agent. It is being marketed as a pharmaceutical gel product. The conclusion that the essential oil of Piper aduncum L. (matico) does not help prevent, much less eliminate the new coronavirus and its chemical composition of the matico only helps prevent some of the symptoms of Covid 19.

Resumo El principal objetivo fue conocer las propiedades antimicrobianas de Piper aduncum L. (matico) para el tratamiento preventivo de Covid-19. El aceite esencial, al igual que los extractos de las hojas y la corteza, son muy valiosos como agente curativo, antibacteriano y antifúngico. De esta forma, los componentes flavonoides presentes en el aceite esencial de Piper aduncum L. (matico) fortalecen la conectividad de los tejidos al inhibir algunas de las enzimas que pueden hidrolizar el proteoglicano y la malla proteica, lo que podría incrementar el efecto antibacteriano al obstaculizar la propagación de la infección al tejido, su actividad antibacteriana contra Staphylococus aureus y Echerichia coli; Como resultado, los metabolitos secundarios como flavonoides, compuestos fenólicos, esteroides y alcaloides tienen acción antibacteriana. La planta Piper aduncum L. (matico) es un buen agente curativo y antifúngico. Se comercializa como un producto farmacéutico en gel. La conclusión de que el aceite esencial de Piper aduncum L. (matico) no ayuda a prevenir, mucho menos eliminar el nuevo coronavirus y su composición química del matico solo ayuda a prevenir algunos de los síntomas de Covid 19.

Encapsulation of Piper aduncum and Piper hispidinervum essential oils in gelatin nanoparticles: a possible sustainable control tool of Aedes aegypti, Tetranychus urticae and Cerataphis lataniae.

BACKGROUND: The encapsulated essential oils (EOs) of Piper aduncum L. and Piper hispidinervum C. DC. in gelatin nanoparticles were evaluated against Aedes aegypti Linn., Tetranychus urticae Koch and Cerataphis lataniae Boisd. RESULTS: Encapsulation efficiency of the EOs was measured for absolute concentrations of 500 µg mL-1 (79.2 and 72.7%) and 1000 µg mL-1 (84.5 and 82.2%). The loaded nanoparticles were nearly spherical and well dispersed. The nanoparticles loaded with P. hispidinervum EO had an average size of 100 ± 2 nm, while the nanoparticles containing P. aduncum EO ranged from 175 ± 4 to 220 ± 4 nm. According to zeta potential analysis, the nanoparticles loaded with P. hispidinervum and P. aduncum EOs presented values around -43.5 ± 3 and -37.5 ± 2 mV respectively. The controlled release of EOs was described by the anomalous mechanism of Korsmeyer-Peppas. Both encapsulated EOs reached lethal dosages within 24 h of exposure and total mortality of the tested pests. CONCLUSION: The present work successfully developed gelatin-based nanoparticles that served as carriers for the EOs of P. aduncum and P. hispidinervum to be applied as a sustainable control tool of A. aegypti, T. urticae and C. lataniae. The developed loaded nanoparticles presented high encapsulation efficiency and EO concentration release higher than lethal dosages. This indicates that it is feasible to use gelatin-based nanoparticles loaded with P. aduncum and P. hispidinervum EOs to control the tested pests. © 2018 Society of Chemical Industry.

Antifungal activity of extracts from Piper aduncum leaves prepared by different solvents and extraction techniques against dermatophytes Trichophyton rubrum and Trichophyton interdigitale

The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.

Antifungal activity of extracts from Piper aduncum leaves prepared by different solvents and extraction techniques against dermatophytes Trichophyton rubrum and Trichophyton interdigitale.

The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.